Different factors affect or modify the various types of toxicity. The factors can be classified as either biological, environmental or chemical. Dose and the actual intake of a toxic product affect the toxicity of different products. In addition, the routes of exposures influence metabolic pathway, translocation, and absorption (Goldfrank, 2002). Moreover, environmental factors including temperature, barometric pressure, and humidity have been affecting the toxicity of a product. Environmental factors affect the occurrence and consumption of different toxic agents. The plants that produce toxic products are usually seasonal and depend on the climatic condition that is among the environmental condition.
Biological factors that modify the toxicity of products include the species of the organisms producing the toxin. Goldfrank (2002) argues that various types or species affect the significance of toxicosis. Size and the age of the organism producing the toxic product have been a biological factor modifying toxicity. Other biological factors include dietary and nutritional factors, stress, gender, health and hormonal status. Chemical factors modifying toxicity include the solubility of the toxicant that has been effective in influencing their absorption. Goldfrank (2002) postulates that the adjuvants are examples of formulation factors that are applied in altering the toxicology impact of a toxin.
Gender is an essential factor that influences toxicity. Goldfrank (2002) asserts that physiologic differences among women and men that include pharmacodynamics and pharmacokinetics have been useful in affecting the impacts of drugs on their body. The pharmacokinetics in a female can be influenced by slower motility of their gastrointestinal, slower function of their kidney, the lower weight of their bodies and reduced enzymatic activities in the intestines. There exist differences between men and women about pharmacodynamics where female have greater effectiveness and sensitivity about toxins relative to male. A middle-aged man who smokes is likely to suffer lung diseases as compared to woman of the same age. Goldfrank (2002) argues that men are more susceptible to said toxins relative to men.
Goldfrank, L. R. (2002). Goldfrank’s toxicologic emergencies. New York: McGraw-Hill Medical Pub. Division.